An experiment for the measurement of the bound-beta decay of the free neutron

The hyperfine-state population of hydrogen after the bound-beta decay of the neutron directly yields the neutrino left-handedness or a possible right-handed admixture and possible small scalar and tensor contributions to the weak force. Using the through-going beam tube of a high-flux reactor, a background free hydrogen rate of ca. 3 s$^{-1}$ can be obtained. The detection of the neutral hydrogen atoms and the analysis of the hyperfine states is accomplished by Lamb shift source type quenching and subsequent ionization. The constraints on the neutrino helicity and the scalar and tensor coupling constants of weak interaction can be improved by a factor of ten.Comment: 9 pages, 5 figures. Submitted to EPJ

How Germany achieved a record share of renewables during the COVID-19 pandemic while relying on the European interconnected power network

In 2020, Germany reached a maximum share of 50.5% intermittent renewables in electricity generation. Such a high share results in an increasing need for flexibility measures such as international transmission flexibility, i.e., electricity imports and exports. In fact, during the COVID-19 pandemic, Germany changed from a former electricity net exporter to a net importer. This paper, therefore, analyzes what we can learn from the resulting development of German electricity imports as a flexibility measure from a market, environmental, and network perspective. We analyze data on electricity imports/exports, generation, prices, and interconnection capacities of 38 bidding zones, respectively 11 countries within the ENTSO-E. In particular, we formulate three hypotheses to partition our overarching research question. Our results reveal that from a market perspective, Germany's increased need for transmission flexibility did not generally result in increased prices for German electricity imports. Also, from an environmental perspective, Germany increasingly relied on electricity imports from countries that exhibited a lower share of renewables. Finally, during the COVID-19 pandemic some of Germany's interconnection capacities to its neighboring countries exhibited a higher utilization. In view of our results, German policymakers may reflect on decarbonization policies considering a holistic European perspective

Gross motor performance and physical fitness in children with psychiatric disorders

0.05) than the population norm score. Physical fitness was poor in all subgroups. The subdomains locomotion and object control were unusually highly correlated in the PDD group (r=0.68). Moreover, only in the PDD group were the locomotion scores significantly correlated with neuromotor fitness (r=0.47, p=0.02). Interpretation The specific combinations of impairments in gross motor skills and physical fitness in children with psychiatric disorders indicate the importance of the assessment of these domains in order to provide interventions tailored to the specific profile of each individual child

Electricity Markets in a Time of Change: A Call to Arms for Business Research

Europe’s clean energy transition is imperative to combat climate change and represents an economic opportunity to become independent of fossil fuels. As such, the energy transition has become one of the most important, but also one of the most challenging economic and societal projects today. Electricity systems of the past were characterized by price-inelastic demand and only a small number of large electricity generators. The transition towards intermittent renewable energy sources changes this very paradigm. Future electricity systems will consist of many thousands of electricity generators and consumers that actively participate in markets, offering flexibility to balance variable electricity supply in markets with a high spatial and temporal resolution. These structural changes have ample consequences for market operators, generators, industrial consumers as well as prosumers. While a large body of the literature is devoted to the energy transition in engineering and the natural sciences, it has received relatively little attention in the recent business research literature, even though many of the central challenges for a successful energy transition are at the core of business research. Therefore, we provide an up-to-date overview of key questions in electricity market design and discuss how changes in electricity markets lead to new research challenges in business research disciplines such as accounting, business & information systems engineering, finance, marketing, operations management, operations research, and risk management

Treatment of RET-Positive Advanced Medullary Thyroid Cancer with Multi-Tyrosine Kinase Inhibitors — A Retrospective Multi-Center Registry Analysis

SIMPLE SUMMARY: Lately, a more personalized approach in the management of advanced thyroid cancer patients has improved the outcomes, and several novel molecularly guided therapies, including selective RET inhibitors (sRETis), have demonstrated promising efficacy in clinical trials. RET (rearranged during transfection) variants are the most prevalent oncogenic event in medullary thyroid cancer (MTC). We here found RET oncogene variants in 44/48 prospectively collected MTC tumor samples from patients treated with more unselective kinase inhibitors vandetanib and/or cabozantinib. Our study shows that RET variants were highly prevalent in patients with advanced MTC, and the treatment results in RET-positive cases were similar to those reported in unselected cohorts. ABSTRACT: Background: RET (rearranged during transfection) variants are the most prevalent oncogenic events in medullary thyroid cancer (MTC). In advanced disease, multi-tyrosine kinase inhibitors (MKIs) cabozantinib and vandetanib are the approved standard treatment irrespective of RET status. The actual outcome of patients with RET-positive MTC treated with MKIs is ill described. Methods: We here retrospectively determined the RET oncogene variant status with a targeted DNA Custom Panel in a prospectively collected cohort of 48 patients with advanced MTC treated with vandetanib and/or cabozantinib at four German referral centers. Progression-free survival (PFS) and overall survival (OS) probabilities were estimated using the Kaplan-Meier method. Results: In total, 44/48 (92%) patients had germline or somatic RET variants. The M918T variant was found in 29/44 (66%) cases. In total, 2/32 (6%) patients with a somatic RET variant had further somatic variants, while in 1/32 (3%) patient with a germline RET variant, additional variants were found. Only 1/48 (2%) patient had a pathogenic HRAS variant, and no variants were found in 3 cases. In first-line treatment, the median OS was 53 (95% CI (95% confidence interval), 32–NR (not reached); n = 36), and the median PFS was 21 months (12–39; n = 33) in RET-positive MTC patients. In second-line treatment, the median OS was 18 (13–79; n = 22), and the median PFS was 3.5 months (2–14; n = 22) in RET-positive cases. Conclusions: RET variants were highly prevalent in patients with advanced MTC. The treatment results in RET-positive cases were similar to those reported in unselected cohorts

Energieflexibilitätsdatenmodell der Energiesynchronisationsplattform: Teil der Reihe Diskussionspapiere V4 Konzept der Energiesynchronisationsplattform

Das im Rahmen von SynErgie entwickelte Energieflexibilitätsdatenmodell dient zur generischen und standardisierten Beschreibung sowie Modellierung von Energieflexibilität. Das Datenmodell ermöglicht eine (teil-)automatisierte informationstechnische Verarbeitung unterschiedlichster Flexibilität. Ziel ist es, ein umfassendes Datenmodell zu entwickeln, um Flexibilität in einem Flexibilitätsraum und konkreten Flexibilitätsmaßnahmen abzubilden. Dabei wird kein vollständig realitätsgetreues Abbild einer Flexibilität angestrebt. Der Fokus liegt auf der Abbildung technisch und energetisch relevanter Informationen in einer Granularität, die eine Kommunikation von Flexibilität zwischen Industrieunternehmen und Energiemärkten ermöglicht.The energy flexibility data model developed within the framework of SynErgie is used for the generic and standardised description and modelling of energy flexibility. The data model enables (partially) automated information technology processing of a wide variety of flexibility. The aim is to develop a comprehensive data model to map flexibility in a flexibility space and concrete flexibility measures. The aim is not to create a completely realistic representation of a flexibility. The focus is on mapping technically and energetically relevant information in a granularity that enables the communication of flexibility between industrial companies and energy markets

Successful direct acting antiviral (DAA) treatment of HCV/HIV-coinfected patients before and after liver transplantation

Objectives The aim of this multicenter retrospective study was to investigate safety and efficacy of direct acting antiviral (DAA) treatment in the rare subgroup of patients with HCV/HIV-coinfection and advanced liver cirrhosis on the liver transplant waiting list or after liver transplantation, respectively. Methods When contacting 54 German liver centers (including all 23 German liver transplant centers), 12 HCV/HIV-coinfected patients on antiretroviral combination therapy were reported having received additional DAA therapy while being on the waiting list for liver transplantation (patient characteristics: Child-Pugh A (n = 6), B (n = 5), C (n = 1);MELD range 7-21;HCC (n = 2);HCV genotype la (n = 8), 1 b (n = 2), 4 (n = 2)). Furthermore, 2 HCV/HIV-coinfected patients were denoted having received DAA therapy after liver transplantation (characteristics: HCV genotype 1a (n = 1), 4 (n = 1)). Results Applied DAA regimens were SOF/DAC (n = 7), SOF/LDV/RBV (n = 3), SOF/RBV (n = 3), PTV/r/OBV/DSV (n = 1), or PTV/r/OBV/DSV/RBV (n = 1), respectively. All patients achieved SVR 12, in the end. In one patient, HCV relapse occurred after 24 weeks of SOF/DAC therapy;subsequent treatment with 12 weeks PTV/r/OBV/DSV achieved SVR 12. One patient underwent liver transplantation while on DAA treatment. Analysis of liver function revealed either stable parameters or even significant improvement during DAA therapy and in followup. MELD scores were found to improve in 9/13 therapies in patients on the waiting list for liver transplantation;in only 2 patients a moderate increase of MELD scores persisted at the end of follow-up. Conclusion DAA treatment was safe and highly effective in this nation-wide cohort of patients with HCV/HIV-coinfection awaiting liver transplantation or being transplanted